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HYPERTENSION CHARACTERIZATION

Nutri meter

BIO-MONITORS

  • Individuals with on-going elevated NT-proBNP are at significant risk for heart failure.
  • NT-proBNP is a hormone that is released into plasma from myocardial cells during ongoing strain or stress. It differs from BNP which is an acute phase reactant that is measured in patients with cardiac or pulmonary distress.
  • Increased levels are seen in subclinical cardiovascular disease indicating possible left ventricular dysfunction, coronary ischemia, hypertensive disorders or underlying atherosclerosis. Additionally, elevated levels are seen in various breathing disorders.
  • Treat and monitor hypertension, using 24 hour blood pressure monitoring if needed. Individuals respond well to ACEs and ARBs in addition to appropriate lifestyle changes, especially weight loss (if needed) and sodium restriction.
  • Find and treat the underlying cause of ongoing strain on the myocardium.
  • Repeat abnormal results every 3 to 6 months until treatment goal is met, then annually.
  • Individuals with high homocysteine levels are 2 times as likely to develop coronary artery disease.
  • Hyperhomocysteinemia causes an irritation to blood vessels, impacting endothelial function. Additionally, high levels impact the availability of nitric oxide, a potent vasodilator, leading to hypertension, further accelerating the atherosclerotic process.
  • Homocysteine levels may be elevated due to dietary deficiencies of folate, B12 or B6 vitamins or due to MTHRF gene mutations limiting its conversion to methionine.
  • Treat with folic acid and B vitamins based on homocysteine levels. Consider secondary causes of elevated levels such as renal insufficiency.
  • Repeat homocysteine every 2 months until treatment goal is met.

MICRONUTRIENT TESTS ASSOCIATED WITH HYPERTENSION

Nutri meter
Biotin
Pharmacological doses reduce systolic blood pressure by activating an enzyme (cGMP) that causes smooth muscle to relax.

Vitamin A
Suppresses the growth of vascular smooth muscle, thus keeping blood vessels (lumen) clear and wide.

Vitamin B2
People with a certain gene (called MTHFR type TT) tend to respond well to B2 therapy for lowering blood pressure.

Vitamin B6
Lowers homocysteine, a toxin that makes arteries stiff and raises blood pressure; Low B6 is strongly linked to hypertension.

Vitamin C
Improves the ability of blood vessels to react appropriately to relaxation signals; Increases nitric oxide, a powerful vasodilator.

Vitamin D
Low vitamin D is strongly linked to hypertension, possibly due to its role in calcium transport; Augments blood pressure lowering effect of calcium; Keeps blood vessels smooth and healthy.

Vitamin E
Increases nitric oxide synthase, an enzyme that causes blood vessels to dilate; Protects blood vessels from damage.

Coenzyme Q10
Improves bioenergetics of blood vessel wall; Deficiency highly correlated to hypertension; Benefits of CoQ10 often not seen for several weeks.

Lipoic Acid
Improves vascular tone; Causes vasodilation; Works like calcium channel blocker meds; Recycles vitamins C, E and cysteine.
Cysteine
Anti-hypertensive effects stem from its role as a potent antioxidant; Effective vasodilator.

Oleic Acid
The benefits of olive oil for blood pressure are largely due to its high oleic acid content, which protects endothelial cells (inner lining of blood vessels) from inflammation.

Carnitine
Lowers blood pressure in the same way as ACE inhibitors, a common hypertension drug which reduces angiotensin, a substance that causes arteries to constrict; Its role in fat metabolism explains this effect.

Folate
Lowers blood pressure by improving endothelial function, or the ability of blood vessels to properly dilate.

Calcium
Optimal calcium status reduces vasoconstriction; Particularly effective for salt-sensitive hypertension as it increases sodium excretion.

Magnesium
Promotes dilation of blood vessels; Low intracellular levels are a well established cause of hypertension.

Copper
Regulates enzymes that keep blood vessels dilating properly; Depletion causes hypertension; Supplementation trials positive.

Zinc
Regulates angiotensin and endothelin, two enzymes that directly affect blood pressure; Deficiency causes blood vessels to constrict.